Author: H. E. Lehmann
Once dementia praecox had been established as a nosological entity by Kraepelin, an entity which was later extended by Bleuler to encompass the whole concept of the schizophrenias, the search for some physical treatment
of this condition began in earnest. Since no single cause of schizophrenia has ever been found, no systematic, rationally focused research in this field could be mounted, except for some isolated attempts to test certain hypotheses. As a result, empirical experiments with a very large number of treatments were conducted by many clinicians all over the world, involving such varied approaches as the administration of manganese1 , or the production of sterile abscesses, and such heroic procedures as the artificial induction of aseptic meningitis.