Author: David Rosenthal
It should be clear at the outset that if we understand the genetics of schizophrenia, we are in a favorable position to develop optimal preventive and therapeutic measures with respect to this grave mental disturbance. The fact is that we do not understand the genetics of schizophrenia. In truth, the primary task of genetic research on this disorder over the past six decades has been to show that heredity has anything to do with schizophrenia at all. The burden of proof has not been borne easily, despite the fact that the conception of the disorder by its originators, Kraepelin and Bleuler, took place in an intellectual climate which assumed almost without question that the disorder was indeed inherited. In this article, we will review the main body of genetic evidence gathered to date and try to place a fair evaluation on it.